Clinical Program Drug Step Therapy – Commercial and Individual Exchange plans, also referred to as UnitedHealthcare Individual & Family ACA Marketplace plans
For fully insured UnitedHealthcare Commercial members in New Jersey, this program is called First Start.
Step programs are targeted towards therapeutic classes that have multiple medication options. While clinical effectiveness may be similar among medication options in a therapeutic class, pricing and factors promoting optimal drug use can vary. Step therapy programs require a trial of clinically appropriate alternative(s) before allowing coverage for the Step 2 medications. Prior to the implementation of a step therapy program, there are several components that are incorporated into its development. This includes, if available, an evaluation of peer-reviewed medical literature which includes randomized clinical trials, drug comparison studies, pharmacoeconomic studies, outcomes research data, published clinical practice guidelines, comparisons of efficacy, side effects, potential for off label use and claims data analysis. Review of step therapy also includes a valuation of benefits, risks, and impacts on members. Step programs are submitted to the UnitedHealthcare Pharmacy and Therapeutics Committee, which includes external physicians representing a broad range of specialties and sub-specialties, medical directors and pharmacists for review and approval prior to implementation.
Several states have enacted legislation requiring that step therapy exception requests (also referred to as step therapy override exceptions) must be approved if the member meets certain conditions or situations. Please contact the OptumRx Prior Authorization department at 1-800-711-4555 or https://professionals.optumrx.com/prior-authorization.html to determine if you qualify for an exception.
Individual Exchange Step Therapy
Find state-specific clinical criteria at Individual Exchange Plan Information for Providers.
Commercial Step Therapy
Inclusion in this list does not indicate a drug is covered by a particular plan. Any drug may be subject to other requirements including but not limited to Exclude at Launch and or Review at Launch.
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Actemra® (tocilizumab), Actemra (tocilizumab) ACTPen, and Tyenne® (tocilizumab-aazg) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2025
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ADHD - Azstarys® (serdexmethylphenidate and dexmethylphenidate), Jornay PM® (methylphenidate extended-release) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.17.2024
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Agamree® (vamorolone) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Akeega™ (niraparib and abiraterone acetate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Antidepressants - Auvelity® (dextromethorphan/bupropion), Trintellix (vortioxetine) and Fetzima® (levomilnacipran) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Azilect (rasagiline) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.14.2022
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Berinert® (C1 esterase inhibitor [human]) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.22.2024
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Bimzelx® (bimekizumab-bkzx) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2025
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Bosulif® (bosutinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Braftovi® (encorafenib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2023
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Bronchitol® (mannitol) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Brukinsa® (zanubrutinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Caplyta® (lumateperone) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Cayston® (aztreonam for inhalation solution) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Cetrotide® (cetrorelix acetate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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CGRP Receptor Antagonists - Aimovig® (erenumab), Ajovy® (fremanezumab), Emgality® (galcanezumab) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Chenodal™ (chenodiol) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2025
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Cipro® HC (ciprofloxacin/hydrocortisone) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Crexont™ (carbidopa/levodopa extended-release), Rytary® (carbidopa/levodopa extended-release) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Crinone® (progesterone gel) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2025
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Diabetes Medications - DPP4 Inhibitors - Januvia® (sitagliptin), Janumet® (sitagliptin/metformin immediate-release), Janumet® XR (sitagliptin/metformin extended-release), Sitagliptin (Zituvio™ authorized generic), Sitagliptin/Metformin (Zituvimet authorized generic), Zituvio (sitagliptin), Zituvimet, Zituvimet XR (sitagliptin/metformin extended-release) - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Dulera® (mometasone furoate/formoterol fumarate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Elmiron® (pentosan polysulfate sodium) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2024
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Emflaza® (deflazacort) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Esperoct® (antihemophilic factor [recombinant], glycopegylated-exei) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Eucrisa® (crisaborole) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Extavia® (interferon β-1b) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Forteo® (teriparatide), teriparatide (generic Forteo) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Fruzaqla™ (fruquintinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.01.2024
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Glaucoma Agents - Travatan Z® (travoprost), Vyzulta® (latanoprostene), Zioptan® (tafluprost) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Hepatitis C Direct Acting Antivirals - Epclusa® (sofosbuvir/velpatasvir), Harvoni (ledipasvir/sofosbuvir), Mavyret™ (glecaprevir/pibrentasvir), Sovaldi® (sofosbuvir), Viekira Pak™ (ombitasvir, paritaprevir, and ritonavir tablets; dasabuvir tablets), Zepatier® (elbasvir/grazoprevir) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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Ibsrela® (tenapanor) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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Ilumya® (tildrakizumab-asmn) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Inrebic® (fedratinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Insulin - Apidra (insulin glulisine), Apidra SoloStar (insulin glulisine), Fiasp (insulin aspart), Novolin N (NPH, human insulin isophane), Novolin R (regular, human insulin), Novolin 70/30 (70% NPH, human insulin isophane and 30% regular, human insulin), Novolog (insulin aspart), Novolog Mix 70/30 (70% insulin aspart protamine and 30% insulin aspart) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Insulin Delivery Devices - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Ixinity [coagulation factor IX (recombinant)] - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Juxtapid® (lomitapide) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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ketoconazole foam (generic Extina®) (ketoconazole), Ketodan® (ketoconazole) foam - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.19.2024
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ketoprofen and ketoprofen extended-release - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Kevzara® (sarilumab) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Kineret® (anakinra) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Kisqali® (ribociclib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.15.2025
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Kisqali® Femara® Co-Pack (ribociclib/letrozole) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.15.2025
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Klisyri® (tirbanibulin) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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Levorphanol - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Livdelzi® (seladelpar) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 03.01.2025
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Lorbrena® (lorlatinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Mavenclad® (cladribine) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2025
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Mekinist® (trametinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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Mektovi® (binimetinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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Methyldopa - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.01.2024
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Migraine - Nurtec® ODT (rimegepant), Qulipta™ (atogepant), Ubrelvy™ (ubrogepant), Zavzpret™ (zavegepant) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Mirabegron (generic Myrbetriq®) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.01.2024
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New and Therapeutic Equivalent Medications - Excluded Drug - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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New and Therapeutic Equivalent Medications - Prior Authorization - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Nexletol (bempedoic acid), Nexlizet (bempedoic acid/ezetimibe) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Ocaliva® (obeticholic acid) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 03.01.2025
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Ojjaara™ (momelotinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Olumiant® (baricitinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Orencia® (abatacept) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Palynziq™ (pegvaliase-pqpz) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.22.2024
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Pancreatic Enzyme Replacement - Pancreaze®, Pertzye®, Viokace® - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.07.2024
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Phosphate Binders - Fosrenol® (lanthanum carbonate), Velphoro® (sucroferric oxyhydroxide) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Praluent® (alirocumab) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.01.2024
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Procysbi® (cysteamine bitartrate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.01.2024
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Proton Pump Inhibitors - Nexium® for suspension (esomeprazole), Prevacid® SoluTab™ (lansoprazole), Zegerid® for suspension (omeprazole and sodium bicarbonate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Ravicti® (glycerol phenylbutyrate oral liquid) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Repository Corticotropins - Acthar Gel® (repository corticotropin injection), Purified Cortrophin Gel™ (Repository corticotropin injection USP) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Reyvow® (lasmiditan) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 06.01.2024
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Rubraca® (rucaparib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Savaysa® (edoxaban) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Sedative Hypnotic Agents - Belsomra® (suvorexant), DayVigo® (lemborexant), Quviviq® (daridorexant), Rozerem® (ramelteon) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2024
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SGLT2 Inhibitors - Brenzavvy® (bexagliflozin), Farxiga® (dapagliflozin), Glyxambi® (empagliflozin/linagliptan), Inpefa® (sotagliflozin), Invokana® (canagliflozin), Invokamet (canagliflozin/metformin), Invokamet XR (canaglifloxin/metformin extended-release), Qtern® (dapagliflozin/saxagliptin), Segluromet® (ertugliflozin/metformin), Steglatro® (ertugliflozin), Steglujan® (ertugliflozin/sitagliptin), Xigduo® XR (dapagliflozin/metformin extended-release) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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Siliq® (brodalumab) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Slynd (drospirenone) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.17.2024
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Solosec® (secnidazole) - Step Therapy - UnitedHealthcare Commerciall Plans
Last Published 11.01.2024
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Sprix® (ketorolac) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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Sprycel® (dasatinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Statins - Lescol® XL (brand and generic fluvastatin extended-release), Livalo® (brand and generic pitavastatin calcium), Zypitamag® (pitavastatin magnesium) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.01.2024
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Tafinlar® (dabrafenib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 11.01.2024
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Taltz® (ixekizumab) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Talzenna™ (talazoparib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Tasigna® (nilotinib) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
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Topical Antifungals - Jublia® (efinaconazole) and tavaborole - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.30.2024
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Topical Steroids - Cordran® (flurandrenolide) cream 0.05%, Cordran® (flurandrenolide) lotion 0.05%, Cordran® (flurandrenolide) ointment 0.05%, Cloderm® (clocortolone pivalate) cream 0.1%, Halog® (halcinonide) cream 0.1%, Halog (halcinonide) ointment 0.1%, desonide gel 0.05% - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Trulance® (plecanatide) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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Velsipity™ (etrasimod) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Veregen (sinecatechins) - Step Therapy-UnitedHealthcare Commercial Plans
Last Published 02.01.2024
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Voquezna Dual Pak® (vonoprazan and amoxicillin), Voquezna Triple® Pak (vonoprazan, amoxicillin and clarithromycin) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 10.01.2024
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Vumerity™ (diroximel fumarate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 08.01.2024
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Xhance® (fluticasone propionate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.18.2024
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Xyntha®(antihemophilic factor [recombinant]) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 12.01.2024
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Yonsa® (abiraterone acetate) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 04.22.2025
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Zeposia® (ozanimod) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 02.01.2025
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Zilxi® (minocycline) - Step Therapy - UnitedHealthcare Commercial Plans
Last Published 07.01.2024
UnitedHealthcare makes pharmacy coverage decisions based on an understanding of how our coverage affects total health care. We do this by integrating pharmacy coverage with medical management, accessing information in a database including pharmacy, medical and laboratory data.